Summary
The Hargrove lab harnesses the unique properties of small organic molecules to study the structure, function and therapeutic potential of long noncoding RNAs (lncRNAs).
The discovery of these fascinating biomolecules has caused a paradigm shift in molecular biology and speculation as to their role as the master drivers of diseases such as cancer. At the same time very little is known about their structure and function, leading some to call the field a veritable “Wild West.”
Small molecules are the perfect tools for such exploration, and the Hargrove lab works at the interface of chemistry and biology, employing methods ranging from RNA-targeted small molecule synthesis and array-based pattern recognition to studies of the molecular and cellular biology of nucleic acids.
Collaborations with the Department of Biology as well as colleagues in the School of Medicine ensure that these tools are applied to the most important unsolved problems in the fundamental biology and disease-related actions of long noncoding RNAs.
Affiliations
Structural Biology and Biophysics Program
Pharmacology Sciences Training Program
Duke BioCoRE Program
Duke Center for RNA Biology
Duke Cancer Institute
Fitzpatrick Institute for Photonics
Duke Center for AIDS Research
Center for Biomolecular and Tissue Engineering
Collaborations
Huang Lab, Duke University School of Medicine; Duke Cancer Institute
Li Lab, Robert Wood Johnson Medical School
Mouzakis Lab, Loyola Marymount University
Schapira Lab, University of Toronto
Tolbert Lab, Case Western Reserve University
Zhang Lab, UNC Chapel Hill
Funding
Duke University
NIH (Center for HIV RNA Studies)
NIH Maximizing Investigator’s Research Award
Ralph A. Powe Award (ORAU)
Prostate Cancer Foundation (Young Investigator Award)
DOD CDMRP Prostate Cancer Research Program
Cottrell Scholar Award
Movember Foundation-Prostate Cancer Foundation Challenge Award
Alfred P. Sloan Research Fellowship
RCSA COVID Initiative Award
NSF CAREER Award
Student and Postdoc Funding and Awards
Joe Taylor Adams Fellowship (Duke Chem Dept)
Chemical Computing Group (CCG) MEDI Travel Award
Duke Graduate Chemistry Council Travel Award
Graduate School Conference Travel Award
NIH Structural Biology and Biophysics Program
Burroughs-Wellcome Fellowship in Organic Chemistry (Duke Chem Dept)
Duke Center for RNA Biology Travel Award
Dean’s Summer Research Fellowship
Gordon Research Fellowship
Undergraduate Research Support Independent Study Grant
NIH T32 Ruth L. Kirschstein Training Grant Fellowship
Center for Biomolecular and Tissue Engineering Training Program Lew Fellowship
GAAN Fellowship
Undergraduate Research Support Assistantship Grant
Undergraduate Research Support Travel Grant
Katherine Goodman Stern Fellowship
